Discussion on genetics

  • lovely_allie

    October 16th 2010, 12:54 pm
  • Sex chromosomes aneuploidy is better at tolerating than autosomal auneuploidỵ How come?

    Shouldn't it be the other way around?

  • billclinton408

    October 16th 2010, 1:11 pm
  • what's autosonal auneuploidy???? Sex Chromosomal Aneuploidies (SCA) : Male (XY), Female (XX) caused by the non-disjunction of the 23th sex chromosome during meiosis, Well I guess SCA is more common than the fragile x syndrome and down syndrome. ??? what's ur point anyway?? I don't get it I duno

  • lovely_allie

    October 16th 2010, 1:19 pm
  • chromosomal aneuploidy- an extra chromosome/chromosomes in autosomal chromosomes. If the fetus has this type of genetic mutation than it has less likely chance to survive versus when the fetus has a mutation on the sex chromosomes (gametes). I just don't exactly understand this concept but I just read my notes again and it says that it because the chromosome mutation occurs at the earlier stages of embryo development.

  • lovely_allie

    October 16th 2010, 1:23 pm
  • This concept can relate to questions such as why does most fetus that have down syndrome make it through the live birth versus other fetuses having a mutation such as triploidy (an extra chromosome in all of its chromosome set such as 69, xxx) can't make it through the live birth and died in the fetus?

  • billclinton408

    October 16th 2010, 1:43 pm
  • maybe God will know the answer for u Laugh of loud Laugh of loud

  • lovely_allie

    October 16th 2010, 2:13 pm
  • oh ok I guess I have to ask God then :(

    Dear god...:(

  • katkatt

    October 17th 2010, 12:20 am
  • Dear God, please come down here and do homework for her Grin

  • lovely_allie

    October 17th 2010, 12:21 am
  • This is not hw sis Kat. I was just studying and wanted to understand a concept.

  • katkatt

    October 17th 2010, 12:36 am
  • Then read the chapter about both Sex chromosomes aneuploidy and anautosomal auneuploiđỵ focus on how normal sex chromosomes work (like Biu explained a little bit above), how both sex chromosomes aneuploidy and anautosomal auneuploiđỵ defect in the fetus, what cause, what the result, which disease cause more danger to the fetus, the mom, etc . How these disease are cure, if any ?


    After reading all of these highlight, and you still dónt get it, then ask your professor :). Enjoy your readings during weekend Grin

  • lovely_allie

    October 17th 2010, 10:22 am
  • Using gene therapy can help to lessen the disease but I don't think any of these genetic diseases are curable.

    Some examples of the normal sex chromosomes # are 46 XX (female), 46 XY (male). If there is a mutation in the sex chromosome in diseases like Kleinfelter (47, XXY), there is an extra X chromosome chromosome in this male invidividual and he tends to have problem developing a testis and usually taller than most guys. This is the case of trisomy and it causes my nondisjunction. There are two types of nondisjunction and it only in the anaphase phase of the meiotic cycle of games. The first one occurs in the Meiosis I, which causes by the not separating homogue pairs and this mutation will cause an individual to have none normal gametes. Their gametes will have an extra chromosome called trisomic and losing a chromosome called monosomic. It is better to have meiosis II nondisjunction, then at least there are some normal cells. The reason for this is the first stage of meiosis could separate normally and when it gets to the second stage, one of the cells can't separate the sister chromatids causing two cells to have an extra chromosome and one cell to miss a chromosome. But the other cell that could separate normally, it produces normal gametes.

  • lovely_allie

    October 17th 2010, 10:23 am
  • For me, I don't like to read the book. I take a lot of notes in class and study from my notes and referring to the powerpoint. I understood it but I was not sure. I just wanted someone who already taken genetic course to clarify the point.

  • lovely_allie

    October 17th 2010, 10:35 am
  • For the question that I asked, let me answer my own question. Sex chromosome aneuploidy is more tolerant than autosomal aneuploidy (fetus that has a sex chromosome aneuploidy has more chance to develop to full term versus having autosomal aneuploidy), because sex chromosome aneuploidy occurs in the later stage of embryonic development.


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